Targeted Cardiovascular Therapy Using Nanoparticles: Advances and Perspectives

Authors

  • Haniyeh Janat Sadeghi * Department of Medical Laboratory Sciences, Islamic Azad University, Zahedan, Iran.
  • Setareh Amiri Department of Medical Laboratory Sciences, Islamic Azad University, Zahedan, Iran.
  • Samira Saheli Department of Medical Laboratory Sciences, Islamic Azad University, Zahedan, Iran.

https://doi.org/10.48314/nna.vi.59

Abstract

Cardiovascular Diseases (CVDs) remain the leading cause of mortality worldwide, posing substantial public health and economic burdens despite remarkable progress in modern medicine. Conventional pharmacological and surgical interventions often lack tissue specificity, resulting in systemic side effects and suboptimal therapeutic efficacy. In recent years, nanotechnology has emerged as a promising platform for the diagnosis and treatment of CVDs, enabling targeted drug delivery, enhanced bioavailability, and controlled release of therapeutic agents. Various classes of nanoparticles, including lipid-based, polymeric, metallic, and biomimetic systems, have been engineered to deliver drugs, genes, or imaging agents directly to diseased cardiovascular tissues. These nanocarriers can be tailored to recognize specific molecular markers or respond to pathological stimuli, thereby improving selectivity and therapeutic precision. Despite encouraging preclinical outcomes, several barriers continue to hinder clinical translation, such as limited biocompatibility data, immune system clearance, manufacturing scalability, and stringent regulatory requirements. This review provides an up-to-date overview of nanoparticle-based targeted therapies in cardiovascular medicine, highlighting current design strategies, therapeutic applications, and remaining challenges. It also discusses future perspectives and translational considerations to advance the development of safe and effective cardiovascular nanotherapeutics.

Keywords:

Nanoparticles, Targeted therapy, Cardiovascular diseases, Drug delivery, Nanomedicine

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Published

2025-03-21

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Vol. 1 No. 1 (2025): Nano Nexus & Applications (NNA)

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Articles

How to Cite

Janat Sadeghi , H. ., Amiri , S. ., & Saheli, S. . . (2025). Targeted Cardiovascular Therapy Using Nanoparticles: Advances and Perspectives. Nano Nexus & Applications, 1(1), 36-48. https://doi.org/10.48314/nna.vi.59