Polymeric Nanoparticles for Targeted Drug Delivery: An Updated Review

Authors

  • Ayda Nikzad * Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.

https://doi.org/10.48314/nna.vi.58

Abstract

Targeted drug delivery via polymeric nanoparticles (PNPs) has emerged as a highly promising strategy to improve therapeutic outcomes while minimizing systemic toxicity. Owing to their unique physicochemical characteristics, such as biocompatibility, biodegradability, and tunable surface properties PNPs can efficiently encapsulate a wide range of therapeutic agents and deliver them selectively to pathological sites. This review provides a comprehensive analysis of the design principles, classification, synthesis methodologies, and surface functionalization strategies of polymeric nanoparticles. Their applications in cancer therapy, gene delivery, and other biomedical domains are critically evaluated. Key challenges, including potential toxicity, scalability of production, and regulatory considerations, are discussed. Finally, future directions emphasizing stimuli-responsive polymers and personalized nanomedicine approaches are highlighted.

Keywords:

Polymeric Nanoparticles, Targeted Drug Delivery, Nanomedicine, Biocompatibility, Drug Release, Cancer therapy

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Published

2025-03-06

Issue

Vol. 1 No. 1 (2025): Nano Nexus & Applications (NNA)

Section

Articles

How to Cite

Nikzad, A. . (2025). Polymeric Nanoparticles for Targeted Drug Delivery: An Updated Review. Nano Nexus & Applications, 1(1), 1-11. https://doi.org/10.48314/nna.vi.58